Version 5.4
Mus musculus Protein: Kif19a
Summary
InnateDB Protein IDBP-214127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kif19a
Protein Name kinesin family member 19A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081398
InnateDB Gene IDBG-214125 (Kif19a)
Protein Structure
UniProt Annotation
Function Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. {ECO:0000269PubMed:23168168}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000305PubMed:23168168}. Cell projection, cilium {ECO:0000269PubMed:23168168}. Note=Localizes to cilia tips.
Disease Associations
Tissue Specificity Strongly expressed in the oviduct and trachea. Expressed in testis, lung, ovary and brain. {ECO:0000269PubMed:11416179, ECO:0000269PubMed:23168168}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008574 plus-end-directed microtubule motor activity
Biological Process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
GO:0060404 axonemal microtubule depolymerization
GO:0070462 plus-end specific microtubule depolymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:2447024
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99PT9
PhosphoSite PhosphoSite-Q99PT9
TrEMBL A9XMT8
UniProt Splice Variant
Entrez Gene 286942
UniGene Mm.308713
RefSeq NP_001096085
MGI ID
MGI Symbol Kif19a
OMIM
CCDS CCDS36367
HPRD
IMGT
EMBL AB054026 AL663079 BC151045 BC151053 EF570784
GenPept AAI51046 AAI51054 ABU49830 BAB32490 CAO82124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca