Version 5.4
Homo sapiens Protein: RBM11
Summary
InnateDB Protein IDBP-227909.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBM11
Protein Name RNA binding motif protein 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383421
InnateDB Gene IDBG-714 (RBM11)
Protein Structure
UniProt Annotation
Function Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1. {ECO:0000269PubMed:21984414}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:21984414}. Nucleus speckle {ECO:0000269PubMed:21984414}. Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles.
Disease Associations
Tissue Specificity Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary gland, spleen and kidney. Also expressed in fetal brain. {ECO:0000269PubMed:12036298, ECO:0000269PubMed:12909339, ECO:0000269PubMed:21984414}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0008266 poly(U) RNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0007275 multicellular organismal development
GO:0008380 RNA splicing
GO:0030154 cell differentiation
GO:0034599 cellular response to oxidative stress
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57052
PhosphoSite PhosphoSite-P57052
TrEMBL D3DSC2
UniProt Splice Variant
Entrez Gene 54033
UniGene Hs.283828
RefSeq NP_658983
HUGO HGNC:9897
OMIM
CCDS CCDS46635
HPRD 10185
IMGT
EMBL AF519623 AK091331 AP001660 AY077695 BC030196 CH471079
GenPept AAH30196 AAL82535 AAM75350 BAA95545 BAC03638 EAX10061 EAX10063

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca