InnateDB Protein
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IDBP-234266.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NETO1
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Protein Name
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neuropilin (NRP) and tolloid (TLL)-like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381024
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InnateDB Gene
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IDBG-4880 (NETO1)
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Protein Structure
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Function |
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Component of the postsynaptic density (PSD) of excitatory synapses. {ECO:0000250}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 1: Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain. {ECO:0000269PubMed:11943477}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000859
CUB domain
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PFAM |
PF00431
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PRINTS |
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PIRSF |
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SMART |
SM00042
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TDF5
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PhosphoSite |
PhosphoSite-Q8TDF5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
81832
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UniGene |
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RefSeq |
NP_620552
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HUGO |
HGNC:13823
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OMIM |
607973
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CCDS |
CCDS42444
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HPRD |
16264
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IMGT |
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EMBL |
AC023301
AC091138
AF448838
AF448839
AL834354
BC050329
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GenPept |
AAH50329
AAM18026
AAM18027
CAD39019
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