InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf19

Summary

InnateDB Protein

IDBP-258562.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf19

Protein Name

tumor necrosis factor receptor superfamily, member 19

Synonyms

AL023044; AW123854; TAJ; TAJ-ALPHA; TRADE; Troy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106867

InnateDB Gene

IDBG-170947 (Tnfrsf19)

Protein Structure

UniProt Annotation

Function

Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors. {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 4: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1352474

InterPro

IPR001368 TNFR/NGFR cysteine-rich region
IPR022342 Tumour necrosis factor receptor 19

PFAM

PF00020

PRINTS

PR01969

PIRSF

SMART

SM00208

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLL3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

29820

UniGene

Mm.398629

RefSeq

NP_001157627

MGI ID

MGI Symbol

Tnfrsf19

OMIM

CCDS

CCDS36941

HPRD

IMGT

EMBL

AB040432 AB040433 AF167552 AF167553 AF167554 AF173166 AF247000 AK028146 BC030062

GenPept

AAF19795 AAF71825 AAF71826 AAF71827 AAH30062 AAK28397 BAB03267 BAB03268 BAC25774