InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prl2c2

Summary

InnateDB Protein

IDBP-259936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prl2c2

Protein Name

prolactin family 2, subfamily c, member 2

Synonyms

MRP-1; Plf; PLF-1; Plf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106224

InnateDB Gene

IDBG-259934 (Prl2c2)

Protein Structure

UniProt Annotation

Function

May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells. {ECO:0000269PubMed:11316781, ECO:0000269PubMed:16876275}.

Subcellular Localization

Secreted {ECO:0000269PubMed:16876275}. Endoplasmic reticulum {ECO:0000269PubMed:16876275}.

Disease Associations

Tissue Specificity

Expressed in brain, cerebellum and in Neuro-2a cell line. Expressed in placenta and hair follicles, with highest expression levels detected in the outer root sheath and no expression detected in bulb (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is expressed in Neuro- 2a cells. Expressed in embryonic fibroblasts and at low levels in keratinocytes. {ECO:0000269PubMed:11316781, ECO:0000269PubMed:16876275}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0002040	sprouting angiogenesis
GO:0002052	positive regulation of neuroblast proliferation
GO:0031346	positive regulation of cell projection organization
GO:0032534	regulation of microvillus assembly
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045662	negative regulation of myoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter