InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acnat1

Summary

InnateDB Protein

IDBP-266127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acnat1

Protein Name

acyl-coenzyme A amino acid N-acyltransferase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103325

InnateDB Gene

IDBG-146950 (Acnat1)

Protein Structure

UniProt Annotation

Function

Acyltransferase which efficiently conjugates very long- chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine. {ECO:0000269PubMed:17116739}.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:17116739}.

Disease Associations

Tissue Specificity

Expressed mainly in liver and kidney with low levels in adrenal and little or no expression in other tissues. {ECO:0000269PubMed:17116739}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016410	N-acyltransferase activity
GO:0016790	thiolester hydrolase activity

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process

Cellular Component

GO:0005777

peroxisome

Protein Structure and Domains

PDB ID

MGI:2140197

InterPro

IPR005645 Serine hydrolase FSH
IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF03959
PF04775
PF08840

PRINTS

PIRSF

PIRSF016521

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2AKK5