InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mup17

Summary

InnateDB Protein

IDBP-266566.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mup17

Protein Name

major urinary protein 17

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103108

InnateDB Gene

IDBG-708524 (Mup17)

Protein Structure

UniProt Annotation

Function

Major urinary proteins (Mups) bind pheromones, thus stabilize them and allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup- suckling, territory establishment and dominance (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Because of their involvement in the coordination of social behavior, Mup proteins are thought to exhibit variable expression depending upon gender, age and status of the studied individuals. Expression may also be strain- specific: in strains C57BL/6J and 129S7, transcriptional support is lacking for Mup17. {ECO:0000269PubMed:18507838}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005215	transporter activity
GO:0005488	binding
GO:0005550	pheromone binding
GO:0036094	small molecule binding

Biological Process

GO:0006810	transport
GO:0008150	biological_process

Cellular Component

GO:0005575	cellular_component
GO:0005576	extracellular region

Protein Structure and Domains

PDB ID

MGI:3705217

InterPro

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002345 Lipocalin
IPR002448 Odour-binding protein
IPR002968 Alpha-1-microglobulin
IPR002971 Major urinary protein
IPR002972 Prostaglandin D synthase
IPR011038 Calycin-like

PFAM

PF00061
PF08212

PRINTS

PR00179
PR01173
PR01215
PR01221
PR01254

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

B5X0G2