InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTHRC1

Summary

InnateDB Protein

IDBP-31719.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTHRC1

Protein Name

collagen triple helix repeat containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330523

InnateDB Gene

IDBG-31717 (CTHRC1)

Protein Structure

UniProt Annotation

Function

May act as a negative regulator of collagen matrix deposition. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269PubMed:21791690}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells. {ECO:0000269PubMed:15618538}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding

Biological Process

GO:0016477	cell migration
GO:0032092	positive regulation of protein binding
GO:0033690	positive regulation of osteoblast proliferation
GO:0043932	ossification involved in bone remodeling
GO:0045669	positive regulation of osteoblast differentiation
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060122	inner ear receptor stereocilium organization
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090103	cochlea morphogenesis
GO:0090177	establishment of planar polarity involved in neural tube closure