InnateDB Protein
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IDBP-361653.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DECR2
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Protein Name
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2,4-dienoyl CoA reductase 2, peroxisomal
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Synonyms
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PDCR; SDR17C1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000399697
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InnateDB Gene
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IDBG-402194 (DECR2)
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Protein Structure
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Function |
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
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Subcellular Localization |
Peroxisome {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002198
Short-chain dehydrogenase/reductase SDR
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PFAM |
PF00106
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PRINTS |
PR00080
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PIRSF |
PIRSF000126
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NUI1
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PhosphoSite |
PhosphoSite-Q9NUI1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26063
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UniGene |
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RefSeq |
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HUGO |
HGNC:2754
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OMIM |
615839
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CCDS |
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HPRD |
16789
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IMGT |
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EMBL |
AE006463
AJ293009
AK128012
AL023881
BC010740
BC011968
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GenPept |
AAH10740
AAH11968
AAK61231
BAC87232
CAB92744
CAC05664
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