InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NETO1

Summary

InnateDB Protein

IDBP-4882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NETO1

Protein Name

neuropilin (NRP) and tolloid (TLL)-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000313088

InnateDB Gene

IDBG-4880 (NETO1)

Protein Structure

UniProt Annotation

Function

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Component of the postsynaptic density (PSD) of excitatory synapses. {ECO:0000250}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 1: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain. {ECO:0000269PubMed:11943477}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0007613	memory
GO:0008542	visual learning
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0097120	receptor localization to synapse
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005576	extracellular region
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0032983	kainate selective glutamate receptor complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse