InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GYG1

Summary

InnateDB Protein

IDBP-60432.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GYG1

Protein Name

glycogenin 1

Synonyms

GSD15; GYG;

Species

Homo sapiens

Ensembl Protein

ENSP00000340736

InnateDB Gene

IDBG-60430 (GYG1)

Protein Structure

UniProt Annotation

Function

Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.

Subcellular Localization

Disease Associations

Glycogen storage disease 15 (GSD15) [MIM:613507]: A metabolic disorder resulting in muscle weakness, associated with the glycogen depletion in skeletal muscle, and cardiac arrhythmia, associated with the accumulation of abnormal storage material in the heart. The skeletal muscle shows a marked predominance of slow-twitch, oxidative muscle fibers and mitochondrial proliferation. {ECO:0000269PubMed:20357282}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005536	glucose binding
GO:0008466	glycogenin glucosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0005980	glycogen catabolic process
GO:0006006	glucose metabolic process
GO:0008152	metabolic process
GO:0044281	small molecule metabolic process