InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkag1

Summary

InnateDB Protein

IDBP-623966.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkag1

Protein Name

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

Synonyms

AA571379; BB036179; Prkaac;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132499

InnateDB Gene

IDBG-181339 (Prkag1)

Protein Structure

UniProt Annotation

Function

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004679	AMP-activated protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016208	AMP binding
GO:0019901	protein kinase binding
GO:0030554	adenyl nucleotide binding
GO:0043531	ADP binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0010628	positive regulation of gene expression
GO:0050790	regulation of catalytic activity
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0031588	AMP-activated protein kinase complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome