Version 5.4
Homo sapiens Protein: C2orf40
Summary
InnateDB Protein IDBP-64678.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C2orf40
Protein Name chromosome 2 open reading frame 40
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000238044
InnateDB Gene IDBG-64676 (C2orf40)
Protein Structure
UniProt Annotation
Function Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:17284679}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269PubMed:17284679}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008054 cyclin catabolic process
GO:0070314 G1 to G0 transition
GO:0090398 cellular senescence
Cellular Component
GO:0005615 extracellular space
GO:0030133 transport vesicle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H1Z8
PhosphoSite PhosphoSite-Q9H1Z8
TrEMBL B8ZZE5
UniProt Splice Variant
Entrez Gene 84417
UniGene
RefSeq NP_115787
HUGO HGNC:24642
OMIM 611752
CCDS CCDS2072
HPRD 13261
IMGT
EMBL AC018878 AF325503 AY358601 BC021742 CH471127
GenPept AAG42321 AAH21742 AAQ88964 AAY15084 EAX01751 EAX01752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca