InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CCL8

Summary

InnateDB Protein

IDBP-682428.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL8

Protein Name

C-C motif chemokine 8

Synonyms

SCYA8;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018757

InnateDB Gene

IDBG-630945 (CCL8)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts monocytes. This protein can bind heparin.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005125	cytokine activity
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0016004	phospholipase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006887	exocytosis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0043085	positive regulation of catalytic activity
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q09141

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

788169

UniGene

Bt.88314

RefSeq

NP_776432

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF399641 BC142112 S67954 S67956

GenPept

AAB29750 AAD14005 AAI42113 AAK94451