Version 5.4
Bos taurus Protein: H3F3A
Summary
InnateDB Protein IDBP-682543.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H3F3A
Protein Name Histone H3.3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000034086
InnateDB Gene IDBG-631055 (H3F3A)
Protein Structure
UniProt Annotation
Function Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR000164 Histone H3/CENP-A
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00622
PIRSF
SMART SM00428
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9F8
PhosphoSite PhosphoSite-Q5E9F8
TrEMBL
UniProt Splice Variant
Entrez Gene 781224
UniGene Bt.90512
RefSeq NP_001014411
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB099028 BC103071 BC134734 BT020962 BT025472
GenPept AAI03072 AAI34735 AAX08979 ABF57428 BAC56518

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca