Version 5.4
Bos taurus Protein: TMLHE
Summary
InnateDB Protein IDBP-683657.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMLHE
Protein Name Trimethyllysine dioxygenase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015469
InnateDB Gene IDBG-632066 (TMLHE)
Protein Structure
UniProt Annotation
Function Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
GO:0050353 trimethyllysine dioxygenase activity
GO:0051213 dioxygenase activity
Biological Process
GO:0045329 carnitine biosynthetic process
GO:0051354 negative regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR003819 Taurine catabolism dioxygenase TauD/TfdA
IPR012776 Trimethyllysine dioxygenase
PFAM PF02668
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VC74
PhosphoSite PhosphoSite-
TrEMBL G3X6X8
UniProt Splice Variant
Entrez Gene 535630
UniGene
RefSeq NP_001069532
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120318 DAAA02070010 DAAA02070011
GenPept AAI20319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca