Version 5.4
Bos taurus Protein: BIKBA
Summary
InnateDB Protein IDBP-684169.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIKBA
Protein Name NF-kappa-B inhibitor alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022183
InnateDB Gene IDBG-632547 (BIKBA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 154 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0010468 regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010888 negative regulation of lipid storage
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043330 response to exogenous dsRNA
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8WNW7
UniProt Splice Variant
Entrez Gene 282291
UniGene Bt.97921
RefSeq NP_001039333
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ420928 BC105484 DAAA02052738
GenPept AAI05485 CAD12786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca