InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HSD3B

Summary

InnateDB Protein

IDBP-686016.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD3B

Protein Name

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase3-beta-hydroxy-Delta(5)-steroid dehydrogenaseSteroid Delta-isomerase

Synonyms

HSD3B;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010992

InnateDB Gene

IDBG-634251 (HSD3B)

Protein Structure

UniProt Annotation

Function

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769	steroid delta-isomerase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016853	isomerase activity
GO:0050662	coenzyme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030868	smooth endoplasmic reticulum membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR013120 Male sterility, NAD-binding

PFAM

PF01370
PF01073
PF02719
PF04321
PF07993

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P14893

PhosphoSite