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InnateDB Protein
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IDBP-686092.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHTF8
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Protein Name
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Chromosome transmission fidelity protein 8 homolog
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Synonyms
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CTF8; DERPC;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000002226
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InnateDB Gene
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IDBG-634319 (CHTF8)
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Protein Structure
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| Function |
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus. Note=Associates with chromatin during S phase. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR018607
Chromosome transmission fidelity protein 8
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| PFAM |
PF09696
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
P0CG11
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
618186
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| UniGene |
Bt.25479
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| RefSeq |
NP_001108441
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AAFC03016849
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| GenPept |
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Version 5.4