Version 5.4
Bos taurus Protein: ADORA3
Summary
InnateDB Protein IDBP-686863.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADORA3
Protein Name Adenosine receptor A3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010057
InnateDB Gene IDBG-635066 (ADORA3)
Protein Structure
UniProt Annotation
Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001609 G-protein coupled adenosine receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0002553 histamine secretion by mast cell
GO:0002687 positive regulation of leukocyte migration
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0043306 positive regulation of mast cell degranulation
GO:0050729 positive regulation of inflammatory response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000466 Adenosine A3 receptor
IPR001634 Adenosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00555
PR00424
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VC81
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 780806
UniGene Bt.40521
RefSeq NP_001098081
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120305
GenPept AAI20306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca