InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: WNK3

Summary

InnateDB Protein

IDBP-689559.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNK3

Protein Name

WNK lysine deficient protein kinase 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021876

InnateDB Gene

IDBG-637533 (WNK3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019869	chloride channel inhibitor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0010765	positive regulation of sodium ion transport
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0032414	positive regulation of ion transmembrane transporter activity
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0051928	positive regulation of calcium ion transport
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:2000021	regulation of ion homeostasis
GO:2000651	positive regulation of sodium ion transmembrane transporter activity
GO:2000682	positive regulation of rubidium ion transport
GO:2000688	positive regulation of rubidium ion transmembrane transporter activity

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain

PFAM

PF00069
PF07714
PF12202

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G3X788

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

HGNC:14543

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02073295 DAAA02073296 DAAA02073297 DAAA02073298 DAAA02073299

GenPept