Version 5.4
Bos taurus Protein: MAP3K10
Summary
InnateDB Protein IDBP-689828.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K10
Protein Name mitogen-activated protein kinase kinase kinase 10
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045078
InnateDB Gene IDBG-637788 (MAP3K10)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043425 bHLH transcription factor binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF00018
PF14604
PF07653
PRINTS PR00109
PR00452
PIRSF
SMART SM00326
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1B7H4
UniProt Splice Variant
Entrez Gene
UniGene Bt.104314
RefSeq
HUGO HGNC:6849
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047073 DAAA02047074 DAAA02047075
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca