Version 5.4
Bos taurus Protein: DNAJB6
Summary
InnateDB Protein IDBP-690401.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJB6
Protein Name DnaJ homolog subfamily B member 6
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001018
InnateDB Gene IDBG-638337 (DNAJB6)
Protein Structure
UniProt Annotation
Function Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in all tissues examined with highest expression in brain and retina and lower levels observed in testis, spleen, heart, liver and kidney. {ECO:0000269PubMed:11896048}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001623 DnaJ domain
PFAM PF00226
PRINTS PR00625
PIRSF
SMART SM00271
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0III6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282215
UniGene Bt.1731
RefSeq NP_776957
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF426743 BC122622
GenPept AAI22623 AAL73393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca