Version 5.4
Bos taurus Protein: TLR4
Summary
InnateDB Protein IDBP-690857.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLR4
Protein Name toll-like receptor 4 precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008190
InnateDB Gene IDBG-638758 (TLR4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001875 lipopolysaccharide receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0002218 activation of innate immune response
GO:0002224 toll-like receptor signaling pathway
GO:0002322 B cell proliferation involved in immune response
GO:0002376 immune system process
GO:0002537 nitric oxide production involved in inflammatory response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007252 I-kappaB phosphorylation
GO:0009617 response to bacterium
GO:0010572 positive regulation of platelet activation
GO:0030890 positive regulation of B cell proliferation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032497 detection of lipopolysaccharide
GO:0032609 interferon-gamma production
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032707 negative regulation of interleukin-23 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032732 positive regulation of interleukin-1 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042116 macrophage activation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045359 positive regulation of interferon-beta biosynthetic process
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050707 regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060729 intestinal epithelial structure maintenance
GO:0060907 positive regulation of macrophage cytokine production
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0046696 lipopolysaccharide receptor complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR017241 Toll-like receptor
PFAM PF01582
PF13676
PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF PIRSF037595
SMART SM00255
SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q6WCD5
UniProt Splice Variant
Entrez Gene 281536
UniGene Bt.9030
RefSeq NP_776623
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY297040 AY957625 DAAA02024656 DQ839567
GenPept AAQ62700 AAX56982 ABH09760

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca