Version 5.4
Bos taurus Protein: FIS1
Summary
InnateDB Protein IDBP-692613.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FIS1
Protein Name Mitochondrial fission 1 protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010389
InnateDB Gene IDBG-640356 (FIS1)
Protein Structure
UniProt Annotation
Function Involed in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0000266 mitochondrial fission
GO:0000422 mitochondrion degradation
GO:0001836 release of cytochrome c from mitochondria
GO:0006626 protein targeting to mitochondrion
GO:0006915 apoptotic process
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008053 mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016559 peroxisome fission
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0051260 protein homooligomerization
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0070584 mitochondrion morphogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0090314 positive regulation of protein targeting to membrane
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005779 integral component of peroxisomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR016543 Mitochondria fission 1 protein
PFAM
PRINTS
PIRSF PIRSF008835
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0I5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615565
UniGene Bt.15342
RefSeq NP_001029956
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102383
GenPept AAI02384

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca