InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NHP2L1

Summary

InnateDB Protein

IDBP-694345.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NHP2L1

Protein Name

NHP2-like protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008022

InnateDB Gene

IDBG-641937 (NHP2L1)

Protein Structure

UniProt Annotation

Function

Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Note=Concentrated in the dense fibrillar component of the nucleolus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000948 Ribosomal protein L7Ae, prokaryotes
IPR002415 H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote
IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
IPR013241 RNase P, subunit Pop3
IPR018492 Ribosomal protein L7Ae/L8/Nhp2 family
IPR029064 50S ribosomal protein L30e-like

PFAM

PF01248
PF08228

PRINTS

PR00884
PR00883
PR00881

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3B8S0