InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: STRA13

Summary

InnateDB Protein

IDBP-694737.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STRA13

Protein Name

Centromere protein X

Synonyms

BHLHB2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005369

InnateDB Gene

IDBG-642294 (STRA13)

Protein Structure

UniProt Annotation

Function

DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to chromatin. Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0031297	replication fork processing
GO:0051301	cell division
GO:0051382	kinetochore assembly

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005694	chromosome
GO:0043240	Fanconi anaemia nuclear complex
GO:0071821	FANCM-MHF complex

Protein Structure and Domains

PDB ID

InterPro

IPR009072 Histone-fold
IPR018552 Centromere protein X

PFAM

PF09415

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2NKU0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

618018

UniGene

RefSeq

NP_001107999

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC111642

GenPept

AAI11643