InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CATSPERD

Summary

InnateDB Protein

IDBP-696672.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CATSPERD

Protein Name

transmembrane protein 146

Synonyms

TMEM146;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002352

InnateDB Gene

IDBG-644050 (CATSPERD)

Protein Structure

UniProt Annotation

Function

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium, flagellum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0030317	sperm motility
GO:0048240	sperm capacitation

Cellular Component

GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0036128	CatSper complex
GO:0042995	cell projection
GO:0097228	sperm principal piece