InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ENOSF1

Summary

InnateDB Protein

IDBP-696747.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENOSF1

Protein Name

Mitochondrial enolase superfamily member 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000031013

InnateDB Gene

IDBG-644132 (ENOSF1)

Protein Structure

UniProt Annotation

Function

Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto- 3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. May down-regulate thymidylate synthase activity, possibly already at the RNA level, by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0016829	lyase activity
GO:0016853	isomerase activity
GO:0046872	metal ion binding
GO:0050023	L-fuconate dehydratase activity

Biological Process

GO:0008152	metabolic process
GO:0009063	cellular amino acid catabolic process
GO:0044275	cellular carbohydrate catabolic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain
IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal
IPR029017 Enolase N-terminal domain-like
IPR029065 Enolase C-terminal domain-like

PFAM

PF02746
PF01188

PRINTS

PIRSF

SMART

SM00922

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KIA9