InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RAX2

Summary

InnateDB Protein

IDBP-696993.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAX2

Protein Name

Retina and anterior neural fold homeobox protein 2

Synonyms

QRX;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012858

InnateDB Gene

IDBG-644361 (RAX2)

Protein Structure

UniProt Annotation

Function

May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Expressed in retina. Stronger expression in cells of the outer nuclear layers than in cells of the inner nuclear layers. Also weakly detected in brain, testis and spleen. {ECO:0000269PubMed:15028672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007601	visual perception
GO:0050896	response to stimulus

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like

PFAM

PF00046

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7YRX0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

359713

UniGene

Bt.87576

RefSeq

NP_872594

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY211276

GenPept

AAP41546