Version 5.4
Bos taurus Protein: TMEM173
Summary
InnateDB Protein IDBP-698791.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM173
Protein Name Transmembrane protein 173
Synonyms STING;
Species Bos taurus
Ensembl Protein ENSBTAP00000002962
InnateDB Gene IDBG-646026 (TMEM173)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035438 cyclic-di-GMP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0061507 cyclic-GMP-AMP binding
Biological Process
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0002376 immune system process
GO:0006915 apoptotic process
GO:0032092 positive regulation of protein binding
GO:0032481 positive regulation of type I interferon production
GO:0032608 interferon-beta production
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0035458 cellular response to interferon-beta
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0071360 cellular response to exogenous dsRNA
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KI99
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 533661
UniGene Bt.11003
RefSeq NP_001039822
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112716
GenPept AAI12717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca