InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ANG2

Summary

InnateDB Protein

IDBP-698818.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANG2

Protein Name

Angiogenin-2

Synonyms

RAA2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000049727

InnateDB Gene

IDBG-646048 (ANG2)

Protein Structure

UniProt Annotation

Function

Binds tightly to placental ribonuclease inhibitor and has very low ribonuclease activity. Has potent angiogenic activity. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA. {ECO:0000250}.

Disease Associations

Tissue Specificity

Serum and milk.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0016787	hydrolase activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0007275	multicellular organismal development
GO:0008152	metabolic process
GO:0017148	negative regulation of translation
GO:0030154	cell differentiation
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR001427 Pancreatic ribonuclease
IPR023412 Ribonuclease A-domain

PFAM

PF00074

PRINTS

PR00794

PIRSF

SMART

SM00092

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P80929

PhosphoSite

PhosphoSite-

TrEMBL

A6H6X2

UniProt Splice Variant

Entrez Gene

783907

UniGene

RefSeq

NP_001092866

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC146030 DAAA02028328 HG329010

GenPept

AAI46031 CDG32086