Bos taurus Protein: PRKAR2A
Summary
InnateDB Protein IDBP-698866.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAR2A
Protein Name cAMP-dependent protein kinase type II-alpha regulatory subunit
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018886
InnateDB Gene IDBG-646091 (PRKAR2A)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004862 cAMP-dependent protein kinase inhibitor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0030552 cAMP binding
GO:0031625 ubiquitin protein ligase binding
GO:0034236 protein kinase A catalytic subunit binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
GO:0031588 AMP-activated protein kinase complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000595 Cyclic nucleotide-binding domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR012198 cAMP-dependent protein kinase regulatory subunit
IPR018490 Cyclic nucleotide-binding-like
PFAM PF00027
PF02197
PRINTS PR00103
PIRSF PIRSF000548
SMART SM00100
SM00394
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00515
PhosphoSite PhosphoSite-P00515
TrEMBL
UniProt Splice Variant
Entrez Gene 100139910
UniGene Bt.9222
RefSeq NP_001178296
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept