Version 5.4
Bos taurus Protein: FNTB
Summary
InnateDB Protein IDBP-699613.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FNTB
Protein Name Protein farnesyltransferase subunit beta
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007751
InnateDB Gene IDBG-646779 (FNTB)
Protein Structure
UniProt Annotation
Function Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004311 farnesyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0004660 protein farnesyltransferase activity
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0018343 protein farnesylation
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0048146 positive regulation of fibroblast proliferation
Cellular Component
GO:0005965 protein farnesyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
PFAM PF00432
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49355
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327686
UniGene Bt.4529
RefSeq NP_786999
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123393 L00633
GenPept AAA30524 AAI23394

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca