Version 5.4
Bos taurus Protein: PPP1R3B
Summary
InnateDB Protein IDBP-701679.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R3B
Protein Name Protein phosphatase 1 regulatory subunit 3B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014032
InnateDB Gene IDBG-648981 (PPP1R3B)
Protein Structure
UniProt Annotation
Function Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0005981 regulation of glycogen catabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR005036 Putative phosphatase regulatory subunit
IPR017434 Protein phosphatase 1, glycogen targeting subunit, Metazoa
PFAM PF03370
PRINTS
PIRSF PIRSF038207
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QNP3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514428
UniGene Bt.59198
RefSeq NP_001096717
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148936
GenPept AAI48937

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca