Mus musculus Protein: Gm10681 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-716419.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Gm10681 | ||||||||||||||
Protein Name | |||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000136749 | ||||||||||||||
InnateDB Gene | IDBG-706255 (Gm10681) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD IV can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Does not function as a isomerase. | ||||||||||||||
Subcellular Localization | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Kidney; found only in the cortex, appears to be associated with the proximal tubules; and a minor expression in testis. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:3711284 | ||||||||||||||
InterPro |
IPR001509
NAD-dependent epimerase/dehydratase IPR002198 Short-chain dehydrogenase/reductase SDR IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase IPR003869 Polysaccharide biosynthesis protein, CapD-like domain IPR005913 dTDP-4-dehydrorhamnose reductase IPR008030 NmrA-like IPR013120 Male sterility, NAD-binding IPR013968 Polyketide synthase, KR |
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PFAM |
PF01370
PF00106 PF01073 PF02719 PF04321 PF05368 PF07993 PF08659 |
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PRINTS |
PR00080
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PIRSF |
PIRSF000126
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SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q61767 | ||||||||||||||
PhosphoSite | PhosphoSite-XP_003084582 | ||||||||||||||
TrEMBL | Q3UIU9 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 15495 | ||||||||||||||
UniGene | Mm.440558 | ||||||||||||||
RefSeq | XP_006500871 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Gm10681 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS57247 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AK146749 BC013449 BC132402 L16919 | ||||||||||||||
GenPept | AAA39374 AAH13449 AAI32403 BAE27407 | ||||||||||||||