Version 5.4
Mus musculus Protein: Gm10591
Summary
InnateDB Protein IDBP-717651.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gm10591
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000136903
InnateDB Gene IDBG-710656 (Gm10591)
Protein Structure
UniProt Annotation
Function Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T- cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:3711256
InterPro IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P86793
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 65956
UniGene
RefSeq NP_001180597
MGI ID
MGI Symbol Gm10591
OMIM
CCDS CCDS51158
HPRD
IMGT
EMBL AF171085 AF307986 AF307987 AL824709 AL844494 BC087957 U88322
GenPept AAC17929 AAF16900 AAG45834 AAG45835 AAH87957 CAM22843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca