InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFIT5

Summary

InnateDB Protein

IDBP-81994.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFIT5

Protein Name

interferon-induced protein with tetratricopeptide repeats 5

Synonyms

P58; RI58;

Species

Homo sapiens

Ensembl Protein

ENSP00000360860

InnateDB Gene

IDBG-81992 (IFIT5)

Protein Structure

UniProt Annotation

Function

Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP- RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs. {ECO:0000269PubMed:23317505, ECO:0000269PubMed:23334420}.

Subcellular Localization

Cell projection, ruffle membrane {ECO:0000269PubMed:23317505}. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13325