InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGT1A10

Summary

InnateDB Protein

IDBP-83548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT1A10

Protein Name

UDP glucuronosyltransferase 1 family, polypeptide A10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343838

InnateDB Gene

IDBG-409445 (UGT1A10)

Protein Structure

UniProt Annotation

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269PubMed:19545173}.

Subcellular Localization

Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212). {ECO:0000269PubMed:18004212, ECO:0000269PubMed:9271343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008152	metabolic process
GO:0030259	lipid glycosylation
GO:0051552	flavone metabolic process
GO:0052695	cellular glucuronidation