Homo sapiens Protein: CDKN1A
Summary
InnateDB Protein IDBP-85039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKN1A
Protein Name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Synonyms CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1;
Species Homo sapiens
Ensembl Protein ENSP00000362815
InnateDB Gene IDBG-85033 (CDKN1A)
Protein Structure
UniProt Annotation
Function May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. {ECO:0000269PubMed:8242751, ECO:0000269PubMed:9106657}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 469 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 473 [view]
Protein-Protein 403 [view]
Protein-DNA 64 [view]
Protein-RNA 3 [view]
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0019912 cyclin-dependent protein kinase activating kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 cell cycle arrest
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030308 negative regulation of cell growth
GO:0031668 cellular response to extracellular stimulus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042326 negative regulation of phosphorylation
GO:0045087 innate immune response
GO:0045860 positive regulation of protein kinase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0071479 cellular response to ionizing radiation
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0090398 cellular senescence
GO:0090400 stress-induced premature senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
GO:0070557 PCNA-p21 complex
Protein Structure and Domains
PDB ID
InterPro IPR003175 Cyclin-dependent kinase inhibitor
PFAM PF02234
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P38936
PhosphoSite PhosphoSite-P38936
TrEMBL J3KQV0
UniProt Splice Variant
Entrez Gene 1026
UniGene Hs.370771
RefSeq
HUGO HGNC:1784
OMIM 116899
CCDS CCDS4824
HPRD 00298
IMGT
EMBL AB451290 AB451422 AF497972 BC000275 BC000312 BC001935 BC013967 BT006719 CH471081 CR536533 L25610 L26165 L47232 L47233 S67388 U03106 U09579 Z85996
GenPept AAA16109 AAA19811 AAA85641 AAB29246 AAB59559 AAB59560 AAC04313 AAH00275 AAH00312 AAH01935 AAH13967 AAM11787 AAP35365 BAG70104 BAG70236 CAB06656 CAG38770 EAX03904 EAX03905 EAX03907