InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fzd7

Summary

InnateDB Gene

IDBG-158403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd7

Gene Name

frizzled homolog 7 (Drosophila)

Synonyms

Fz7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041075

Encoded Proteins

IDBP-252174

frizzled homolog 7 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155760:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Members of the \'frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:59482424-59486955

Strand

Forward strand

Band

Transcripts

ENSMUST00000114246

ENSMUSP00000109884

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008406	gonad development
GO:0010812	negative regulation of cell-substrate adhesion
GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0019827	stem cell maintenance
GO:0030855	epithelial cell differentiation
GO:0033077	T cell differentiation in thymus
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035412	regulation of catenin import into nucleus
GO:0035567	non-canonical Wnt signaling pathway
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0042327	positive regulation of phosphorylation
GO:0042666	negative regulation of ectodermal cell fate specification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048103	somatic stem cell division
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0060070	canonical Wnt signaling pathway
GO:0060231	mesenchymal to epithelial transition

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell