InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fzd7

Summary

InnateDB Protein

IDBP-252174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd7

Protein Name

frizzled homolog 7 (Drosophila)

Synonyms

Fz7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109884

InnateDB Gene

IDBG-158403 (Fzd7)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes. {ECO:0000269PubMed:10097073, ECO:0000269PubMed:15353129}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008406	gonad development
GO:0010812	negative regulation of cell-substrate adhesion
GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0019827	stem cell maintenance
GO:0030855	epithelial cell differentiation
GO:0033077	T cell differentiation in thymus
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035412	regulation of catenin import into nucleus
GO:0035567	non-canonical Wnt signaling pathway
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0042327	positive regulation of phosphorylation
GO:0042666	negative regulation of ectodermal cell fate specification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048103	somatic stem cell division
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0060070	canonical Wnt signaling pathway
GO:0060231	mesenchymal to epithelial transition

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell