InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Col11a2

Summary

InnateDB Gene

IDBG-169769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Col11a2

Gene Name

collagen, type XI, alpha 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024330

Encoded Proteins

IDBP-169773

collagen, type XI, alpha 2

IDBP-252088

collagen, type XI, alpha 2

IDBP-252090

collagen, type XI, alpha 2

IDBP-534938

collagen, type XI, alpha 2

IDBP-535027

collagen, type XI, alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204248:
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34039437-34066685

Strand

Forward strand

Band

Transcripts

ENSMUST00000087497	ENSMUSP00000084772
ENSMUST00000114255	ENSMUSP00000109893
ENSMUST00000114252	ENSMUSP00000109890
ENSMUST00000131134	ENSMUSP00000122082
ENSMUST00000143354	ENSMUSP00000115026
ENSMUST00000137374
ENSMUST00000144927
ENSMUST00000173749

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0001894	tissue homeostasis
GO:0002062	chondrocyte differentiation
GO:0007605	sensory perception of sound
GO:0030199	collagen fibril organization
GO:0048705	skeletal system morphogenesis