InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Artn

Summary

InnateDB Gene

IDBG-180411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Artn

Gene Name

artemin

Synonyms

neublastin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028539

Encoded Proteins

IDBP-180413

artemin

IDBP-180415

artemin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117407:
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:117926162-117929763

Strand

Reverse strand

Band

D2.1

Transcripts

ENSMUST00000097913	ENSMUSP00000095526
ENSMUST00000070816	ENSMUSP00000064521
ENSMUST00000133703
ENSMUST00000150612

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030116	glial cell line-derived neurotrophic factor receptor binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007411	axon guidance
GO:0007422	peripheral nervous system development
GO:0050930	induction of positive chemotaxis
GO:0061146	Peyer's patch morphogenesis
GO:0097021	lymphocyte migration into lymphoid organs

Cellular Component

GO:0005615

extracellular space

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117407

View Gene Order

ENSBTAG00000040060

Not yet available

Pathways

NETPATH

REACTOME

REACT_236183

NCAM1 interactions pathway

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

REACT_237796

NCAM signaling for neurite out-growth pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18312

NCAM1 interactions pathway

REACT_18334

NCAM signaling for neurite out-growth pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.56897

RefSeq

NM_001284191 NM_009711

OMIM

CCDS

CCDS18543

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas