InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Artn

Summary

InnateDB Protein

IDBP-180413.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Artn

Protein Name

artemin

Synonyms

neublastin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095526

InnateDB Gene

IDBG-180411 (Artn)

Protein Structure

UniProt Annotation

Function

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch- like structures, a major component of the gut-associated lymphoid tissue. {ECO:0000250, ECO:0000269PubMed:17322904}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030116	glial cell line-derived neurotrophic factor receptor binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007411	axon guidance
GO:0007422	peripheral nervous system development
GO:0050930	induction of positive chemotaxis
GO:0061146	Peyer's patch morphogenesis
GO:0097021	lymphocyte migration into lymphoid organs