InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lmtk2

Summary

InnateDB Gene

IDBG-208012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmtk2

Gene Name

lemur tyrosine kinase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038970

Encoded Proteins

IDBP-208016

lemur tyrosine kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164715:
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:144100436-144188204

Strand

Forward strand

Band

Transcripts

ENSMUST00000041804

ENSMUSP00000048238

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0070853	myosin VI binding

Biological Process

GO:0001881	receptor recycling
GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032456	endocytic recycling
GO:0033572	transferrin transport
GO:0043086	negative regulation of catalytic activity
GO:0045022	early endosome to late endosome transport
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000164715

View Gene Order

ENSBTAG00000004135

Not yet available

Cross-References

SwissProt

Q3TYD6

TrEMBL

UniProt Splice Variant

Entrez Gene

231876

UniGene

Mm.288726 Mm.397119 Mm.397127 Mm.474987

RefSeq

NM_001081109 XM_006504825

OMIM

CCDS

CCDS39376

HPRD

IMGT

MGI ID

MGI:3036247

MGI Symbol

Lmtk2

EMBL

AB288872 AK039738 AK129279 AK158724 BC058653

GenPept

AAH58653 BAC30433 BAC98089 BAE34627 BAF64833

RNA Seq Atlas

231876