InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lmtk2

Summary

InnateDB Protein

IDBP-208016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmtk2

Protein Name

lemur tyrosine kinase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048238

InnateDB Gene

IDBG-208012 (Lmtk2)

Protein Structure

UniProt Annotation

Function

Phosphorylates PPP1C, phosphorylase b and CFTR. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Mainly expressed in brain, especially in the olfactory bulb, olfactory tubercle, hippocampus, striatum, cerebellum and cerebral cortex. Weakly expressed in skeletal muscle and not expressed in liver. {ECO:0000269PubMed:15005709}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0070853	myosin VI binding

Biological Process

GO:0001881	receptor recycling
GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032456	endocytic recycling
GO:0033572	transferrin transport
GO:0043086	negative regulation of catalytic activity
GO:0045022	early endosome to late endosome transport
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

MGI:3036247

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt