Version 5.4
Mus musculus Gene: Bag3
Summary
InnateDB Gene IDBG-210660.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bag3
Gene Name BCL2-associated athanogene 3
Synonyms AA407278; Bis; mg638
Species Mus musculus
Ensembl Gene ENSMUSG00000030847
Encoded Proteins
IDBP-210662
BCL2-associated athanogene 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151929:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128523583-128546977
Strand Forward strand
Band F3
Transcripts
ENSMUST00000033136 ENSMUSP00000033136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0051087 chaperone binding
Biological Process
GO:0007420 brain development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0021510 spinal cord development
GO:0050821 protein stabilization
GO:0071260 cellular response to mechanical stimulus
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030018 Z disc
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151929
View Gene Order
ENSBTAG00000013641
Not yet available
Cross-References
SwissProt Q9JLV1
TrEMBL
UniProt Splice Variant
Entrez Gene 29810
UniGene Mm.84073
RefSeq NM_013863
OMIM
CCDS CCDS21898
HPRD
IMGT
MGI ID MGI:1352493
MGI Symbol Bag3
EMBL AB041583 AF130471 AK007414 AK016510 AK036675 CH466531
GenPept AAF26840 BAA95066 BAB25024 BAB30278 BAC29531 EDL17651
RNA Seq Atlas 29810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca