InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bag3

Summary

InnateDB Protein

IDBP-210662.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bag3

Protein Name

BCL2-associated athanogene 3

Synonyms

AA407278; Bis; mg638;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033136

InnateDB Gene

IDBG-210660 (Bag3)

Protein Structure

UniProt Annotation

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0051087	chaperone binding

Biological Process

GO:0007420	brain development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010664	negative regulation of striated muscle cell apoptotic process
GO:0021510	spinal cord development
GO:0050821	protein stabilization
GO:0071260	cellular response to mechanical stimulus
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand