Version 5.4
| Homo sapiens Gene: UGT2B28 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-21770.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | UGT2B28 | ||||||||
| Gene Name | UDP glucuronosyltransferase 2 family, polypeptide B28 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000135226 | ||||||||
| Encoded Proteins |
UDP glucuronosyltransferase 2 family, polypeptide B28
UDP glucuronosyltransferase 2 family, polypeptide B28
UDP glucuronosyltransferase 2 family, polypeptide B28
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 4:69280487-69423402 | ||||||||
| Strand | Forward strand | ||||||||
| Band | q13.2 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
| No orthologs found for this gene | |||||||||
| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Glucuronidation pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
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| KEGG |
Retinol metabolism pathway
Pentose and glucuronate interconversions pathway
Starch and sucrose metabolism pathway
Steroid hormone biosynthesis pathway
Ascorbate and aldarate metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Porphyrin and chlorophyll metabolism pathway
Drug metabolism pathway
Drug metabolism pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9BY64 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 54490 | ||||||||
| UniGene | Hs.653154 | ||||||||
| RefSeq | NM_053039 NM_001207004 | ||||||||
| HUGO | HGNC:13479 | ||||||||
| OMIM | 606497 | ||||||||
| CCDS | CCDS3528 CCDS56330 | ||||||||
| HPRD | 05931 | ||||||||
| IMGT | |||||||||
| EMBL | AB451456 AF177272 AF177273 AF177274 | ||||||||
| GenPept | AAK31807 AAK31808 AAK31809 BAG70270 | ||||||||
| RNA Seq Atlas | 54490 | ||||||||